Pow sperm damage

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Epidemiologist Shanna Swan says low counts and changes to sexual development could endanger human species. Writing in a new book, Shanna Swan, an environmental and reproductive epidemiologist at Icahn School of Medicine at Mount Sinai in New York, warns that the impending fertility crisis poses a global threat comparable to that of the climate crisis. Now, Swan says, following current projections, sperm counts are set to reach zero in In the book, Swan and co-author Stacey Colino explore how modern life is threatening sperm counts, changing male and female reproductive development and endangering human life. It points to lifestyle and chemical exposures that are changing and threatening human sexual development and fertility. Such is the gravity of the threats they pose, she argues, that humans could become an endangered species.
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SEMEN STUDIES AND FERTILITY

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Falling sperm counts 'threaten human survival', expert warns | US news | The Guardian

Los Angeles. In no phase of medicine is it more difficult to evaluate etiological factors and therapeutic results than in the problem of infertility. The numerous constitutional and local conditions that can affect fertility of both the husband and the wife are so diversified that in any critical analysis it is difficult to know where to start and when to stop. Results of therapy statistically, on paper, can look impressive, but it is often questionable whether medicine and the physician have triumphed, or whether Nature and coincidence have succeeded.
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Male Infertility and DNA Damage in Doppel Knockout and Prion Protein/Doppel Double-Knockout Mice

The prion protein PrP and Doppel Dpl have many structural and biochemical properties in common, leading to the suggestion that the lack of an obvious phenotype in PrP-deficient mice maybe because of compensation by Dpl. Sperm from both our mutant lines were present at normal concentrations, had normal motility, and no morphological abnormalities. Despite only rarely fertilizing oocytes in vivo , because of an inability to perform the acrosome reaction, mutant sperm were capable of fertilization in vitro , albeit at reduced rates compared to wild type.
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